Intravitreal delivery of NMO-IgG causes primary retinal damage in the absence of optic nerve injury
The retinal dysfunction observed in NMO may primarily be linked to the activation of Müller cells by NMO-IgG, leading to increased C3 secretion, which in turn activates microglia. Therapeutic strategies targeting Müller cell-microglia interactions in NMO-IgG-induced retinopathy could be promising in addressing the underlying retinal pathology in this condition.
Authors
- Kun-Jin Yang
- Quangang Xu (ORCID: https://orcid.org/0000-0002-4507-1377)
- Tingjun Chen (ORCID: https://orcid.org/0000-0002-5717-5755)
- Xintong Xu (ORCID: https://orcid.org/0000-0002-0939-7652)
- Honglu Song (ORCID: https://orcid.org/0000-0003-0752-6956)
- Yuyu Li (ORCID: https://orcid.org/0009-0002-1660-6413)
- Huanfen Zhou (ORCID: https://orcid.org/0000-0002-8170-8195)
- Biyue Chen
- Qianqian Li (ORCID: https://orcid.org/0000-0002-1840-1203)
- Mingming Sun (ORCID: https://orcid.org/0000-0003-4900-7759)
- Shihui Wei (ORCID: https://orcid.org/0000-0003-2910-0446)
- Wanqun Yang (ORCID: https://orcid.org/0000-0002-6602-7340)
- Yanyan Yu (ORCID: https://orcid.org/0000-0002-7366-5826)
Institutions
- Qingdao Agricultural University (CN)
- Bethune International Peace Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s12974-025-03380-z
- Citations
- 1
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China