The Worldwide Problem of Obesity - Comparison of the Effectiveness of Pharmacological Treatment with Semaglutide and Tirzepatide in Reducing Body Weight

Introduction Obesity is a disease that has been affecting an increasing number of people in the last decade. In addition to surgical and dietary treatment, pharmacological treatment plays an important role in its treatment. Obesity is a risk factor for many diseases, including cardiovascular disease and diabetes, and increases the risk of mortality, which is why appropriate treatment is so important. Comparison of pharmacological treatment methods using two preparations from the group of GLP-1 analogues, such as semaglutide and tirzepatide, available for prescription use in European Union countries, may help select the most effective therapy tailored to the patient. Aim of the body The aim of the study was to summarise and compare the two preparations available for use by patients in terms of their mode of action and their impact on body weight reduction. Methods and Materials The following keywords were used to review the literature available in the PubMed database: "obesity", "semaglutide", "tirzepatide", "weight loss after semaglutide treatment", "weight loss after tirzepatide treatment" and "treatment of obesity". We also used literature available in other scientific journals, literature available on Google Scholar and data collected and stored by WHO.