Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway
These results indicate that paeonol significantly inhibits IL-1β-induced ferroptosis and inflammation in chondrocytes, and the underlying mechanism of paeonol against ferroptosis is partly through the AMPK/Nrf2/GPX4 axis.
Authors
- Shuang Lang (ORCID: https://orcid.org/0000-0003-1493-2821)
- Xiongfeng Li (ORCID: https://orcid.org/0000-0002-6432-0762)
- Shuwei Gong (ORCID: https://orcid.org/0000-0002-6285-8884)
- Xuesheng Jiang
Institutions
- Zhejiang Chinese Medical University (CN)
- Huzhou Normal University (CN)
- Huzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fphar.2025.1526623
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55