Difunctionalization of Alkenes toward 3,3-Disubstituted and Dihydrobenzoindolines by Using an Imidazolylidene Palladacyclic Catalyst
The synthesis of valuable 2a,3-dihydrobenzo[<i>cd</i>]indolines was successfully achieved by combining IPr-Pd<sub>cycle</sub>-Oxa<sub>Naphthyl</sub>-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.
Authors
- Zupeng Chen (ORCID: https://orcid.org/0000-0002-7351-3240)
- Weiwei Fang (ORCID: https://orcid.org/0000-0002-2701-5216)
- Hanxiao Yang
- Yue Chen (ORCID: https://orcid.org/0000-0002-8654-9672)
- Dong Lin
Institutions
- Nanjing Forestry University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1021/acs.joc.4c03100
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Forestry University
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province