Natural Compounds and Green Extraction: A Sustainable Approach for Management of Peptic Ulcer

Peptic ulcers have emerged as one of the leading world health problems with regard to the number of people suffering from it and the consequent economic and clinical load. Current therapy is usually on synthetic drugs, which despite their proven efficacy, present notable drawbacks, including side effects and antibiotic resistance. The present review brings emphasis to the considerable potential inherent in natural compounds like flavonoids, alkaloids, and terpenoids as safe, multi-target alternatives. Green chemistry is held to be really transforming the discovery and development of anti-ulcer agents. Supercritical fluid and microwave-assisted extraction methods constitute techniques that have gone green in providing sustainable and novel ways of isolating bioactives. Their successful alignment towards environmental goals and compounding efficacy preservation has made them really appealing. In addition, the application of computer methods, such as QSAR modeling and docking studies, optimizes bioactivity in the virtue of green chemistry. The integration of these advanced approaches marks a transformative change toward sustainable and effective therapies for managing peptic ulcers, addressing both therapeutic and ecological imperatives.