Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex
GCA induced pyroptosis by promoting the interaction between GOLPH3 and MYO18A, resulting in dTGN formation in lung CSCs. Our findings provide a novel molecular insight into the anti-cancer activities of GCA in lung CSCs.
Authors
- Shihua Deng
- Sun-Han Zhang
- Xiaobian Wang
- Yue-Yan Yang
- Zixin Chen (ORCID: https://orcid.org/0000-0002-9707-8263)
- Ying Xu (ORCID: https://orcid.org/0000-0001-7341-8676)
- Teng Liu (ORCID: https://orcid.org/0000-0002-8171-5328)
- Ting Zhang (ORCID: https://orcid.org/0000-0003-4892-8281)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-3998-8939)
- Dongming Wu (ORCID: https://orcid.org/0000-0002-0665-4422)
- Guang-Su Xie
Institutions
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13287-025-04246-0
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Chengdu Medical College
- National Natural Science Foundation of China