Disruption of the sorcin‒PAX5 protein‒protein interaction induces ferroptosis by promoting the FBXL12-mediated ubiquitination of ALDH1A1 in pancreatic cancer
In this study, we revealed the mechanism of action of sorcin, which is a druggable target for inducing ferroptosis, we identified celastrol as a novel agent that induces ferroptosis, and we showed that disrupting the sorcin-PAX5 interaction is a promising therapeutic strategy for treating pancreatic cancer.
Authors
- Shuoqian Ma
- Tianyang Chen (ORCID: https://orcid.org/0000-0003-3142-8176)
- Yahui Ding (ORCID: https://orcid.org/0000-0001-8588-7728)
- Sisi Chen (ORCID: https://orcid.org/0000-0003-4019-5829)
- Wanjing Feng
- Quan Zhang (ORCID: https://orcid.org/0009-0000-6862-9022)
- Yongping Bai (ORCID: https://orcid.org/0000-0002-7316-6066)
Institutions
- Nankai University (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13045-025-01680-8
- Citations
- 10
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 15.18
Funders
- National Natural Science Foundation of China