<i>Aspergillus fumigatus</i> is influenced by mucus accumulation, airway inflammation and cystic fibrosis transmembrane conductance regulator function
Af growth is reduced by mucus dilution, promoted by specific inflammatory cytokines and infection, and is influenced by CFTR function. CF mucus shows pathological differences that promotes Af growth, suggesting an intrinsic defect in this population.
Authors
- Steven M. Rowe (ORCID: https://orcid.org/0000-0001-9045-0133)
- Ashleigh N. Riegler (ORCID: https://orcid.org/0000-0001-7939-6121)
- T. Spencer Poore
- Sixto M. Leal (ORCID: https://orcid.org/0000-0001-6939-9572)
- Susan E. Birket (ORCID: https://orcid.org/0000-0002-6353-6596)
- Levi Schaefers (ORCID: https://orcid.org/0000-0002-0822-0257)
- Anh Nguyen (ORCID: https://orcid.org/0000-0003-2326-0502)
- Anna Solomonik
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1183/23120541.01035-2024
- Citations
- 3
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Cystic Fibrosis Foundation
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases