AC129507.1 is a ferroptosis-related target identified by a novel mitochondria-related lncRNA signature that is involved in the tumor immune microenvironment in gastric cancer
Our nine-lncRNA risk signature could powerfully predict patient prognosis. AC129507.1 promoted the malignant phenotypes of GC cells. AC129507.1 could play a nonnegligible role in GC by promoting the formation of a immunosuppressive tumor microenvironment by inhibiting the initiation of ferroptosis, which needs to be further explored.
Authors
- Donghui Zhou
- Lixiao Liu (ORCID: https://orcid.org/0000-0003-4629-8386)
- Jinxiao Liang (ORCID: https://orcid.org/0000-0001-5970-1141)
- Ming Chen (ORCID: https://orcid.org/0000-0001-5041-9342)
- Shanshan Yu (ORCID: https://orcid.org/0000-0002-5338-3813)
- Cheng Chen (ORCID: https://orcid.org/0000-0002-0586-0646)
Institutions
- Children's Hospital of Zhejiang University (CN)
- Ningbo First Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12967-025-06287-8
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China