Neurological Soft Signs at Presentation in Patients With Pediatric Acute-Onset Neuropsychiatric Syndrome
This cohort study of patients with PANS found a high prevalence of NSSs that may be associated with basal ganglia dysfunction and an association between these NSSs and disease severity that was not associated with younger age. PANS may have a unique profile, suggesting that targeted neurological examinations may support PANS diagnosis.
Authors
- Margo Thienemann (ORCID: https://orcid.org/0000-0002-4952-4775)
- Lü Tian (ORCID: https://orcid.org/0000-0002-5893-0169)
- Jaynelle Gao (ORCID: https://orcid.org/0000-0002-1853-4460)
- Bahare Farhadian
- Melissa A. Silverman (ORCID: https://orcid.org/0009-0001-6007-877X)
- Jennifer Frankovich (ORCID: https://orcid.org/0000-0001-7356-5617)
- Christopher D Stave (ORCID: https://orcid.org/0000-0001-8232-3994)
- Jenny L. Wilson (ORCID: https://orcid.org/0000-0001-6677-869X)
- Paula Tran
- Yuhuan Xie (ORCID: https://orcid.org/0000-0001-6716-1982)
- Jane E. Zebrack (ORCID: https://orcid.org/0000-0001-7954-6177)
- Britta Verhey
- Meiqian Ma
Institutions
- Lucile Packard Children's Hospital (US)
- Oregon Health & Science University (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.0314
- Citations
- 3
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- U.S. Department of Health and Human Services
- North Carolina Department of Health and Human Services
- Global Lyme Alliance
- Oxnard Foundation
- National Institutes of Health
- National Institute of Mental Health
- Stanford Maternal and Child Health Research Institute