Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study
Among older adults at high risk of mobility disability, high plasma MPO was cross-sectionally and, along with MMP7, longitudinally associated with increased odds of MCI and dementia. In contrast, high MMP1 was cross-sectionally associated with reduced odds of MCI.
Authors
- Marissa J. Schafer (ORCID: https://orcid.org/0000-0002-1470-1583)
- Nathan K. LeBrasseur (ORCID: https://orcid.org/0000-0002-2002-0418)
- Christiaan Leeuwenburgh (ORCID: https://orcid.org/0000-0003-0826-4257)
- Elizabeth J. Atkinson (ORCID: https://orcid.org/0000-0002-1191-3775)
- Steven R. Cummings (ORCID: https://orcid.org/0000-0001-8808-260X)
- Roger A. Fielding (ORCID: https://orcid.org/0000-0003-2236-9020)
- Zaira Aversa
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Marco Pahor
Institutions
- Tufts University (US)
- MACOM (United States) (US)
- California Pacific Medical Center (US)
- Jean Mayer Human Nutrition Research Center on Aging (US)
- Mayo Clinic in Arizona (US)
- Institute on Aging (US)
- Mayo Clinic in Florida (US)
- Wake Forest University (US)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1016/j.jnha.2025.100529
- Citations
- 5
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 5.82