Altered Amplitude of Low-Frequency Fluctuation of the Brain Regions Associated with Pain Symptoms and Negative Emotion in Trigeminal Neuralgia

Patients with TN show functional abnormalities in several key brain regions that are involved in pain perception and emotion regulation. These abnormalities primarily manifest as a reduction in spontaneous neural activity. ALFF in the left SFG and right CG is negatively correlated with the severity of pain and negative emotions, indicating that as pain and negative emotions become more severe in patients with TN, neural activity decreases more significantly in specific brain regions. This suggests that the left SFG and right CG may be characteristic brain regions in the pathophysiological mechanism of TN.