Growth Hormone Replacement Therapy in Heart Failure With Reduced Ejection Fraction
This randomized, double-blind, placebo-controlled trial demonstrates that GH replacement therapy in HFrEF patients with GHD improves exercise performance, and left ventricular and right ventricular structure and function, leading to an amelioration of clinical status and health-related quality of life. (Treatment of GHD Associated With CHF; NCT03775993).
Authors
- Alberto M. Marra (ORCID: https://orcid.org/0000-0002-9679-3003)
- Luigi Saccà
- Michele Modestino (ORCID: https://orcid.org/0009-0007-9183-7410)
- Donatella Scarpa
- Valeria Valente (ORCID: https://orcid.org/0000-0002-7858-5550)
- Mariarosaria De Luca (ORCID: https://orcid.org/0000-0002-6727-5725)
- Eduardo Bossone (ORCID: https://orcid.org/0000-0003-2769-9950)
- Stefania Paolillo (ORCID: https://orcid.org/0000-0003-4683-0993)
- Giulia Crisci (ORCID: https://orcid.org/0000-0002-6629-9389)
- Carmen Rainone (ORCID: https://orcid.org/0000-0003-0387-4910)
- Andrea Salzano (ORCID: https://orcid.org/0000-0003-2352-2103)
- Paola Gargiulo (ORCID: https://orcid.org/0000-0003-4622-1725)
- Lavinia Saldamarco (ORCID: https://orcid.org/0009-0002-8360-2965)
- Dario Bruzzese (ORCID: https://orcid.org/0000-0001-9911-4646)
- Federica Giardino (ORCID: https://orcid.org/0009-0000-2943-4628)
- Roberta D’Assante (ORCID: https://orcid.org/0000-0001-6729-374X)
- Giovanni Esposito (ORCID: https://orcid.org/0000-0003-0565-7127)
- Pasquale Perrone Filardi (ORCID: https://orcid.org/0000-0002-3663-0931)
- Francesco Cacciatore (ORCID: https://orcid.org/0000-0003-4720-1427)
- Michele Arcopinto (ORCID: https://orcid.org/0000-0002-7033-2145)
- Antonio Cittadini (ORCID: https://orcid.org/0000-0003-2352-2103)
Institutions
- Karolinska Institutet (SE)
- Fatebenefratelli Hospital (IT)
- Ospedale San Paolo (IT)
- Federico II University Hospital (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.jchf.2024.11.017
- Citations
- 5
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- Merck KGaA