Endocarditis and Hypertrophic Cardiomyopathy
Infective endocarditis (IE) is an uncommon but potentially fatal complication in patients affected by hypertrophic cardiomyopathy (HCM). The risk has been described to be significantly higher than in the general population, but the incidence of IE in HCM population remains unknown. The complex pathophysiology of this disease, characterized by structural alterations of the mitral valve apparatus and the presence of turbulent flow that promotes the deposition of microorganisms, could provide a substrate for IE and may, to some extent, explain its higher incidence in this specific population. The purpose of this case series is to highlight the correlation between endocarditis and HCM, a concern that has also been raised in recent European guidelines.
Authors
- Sebastiano Bertola
- Eustachio Agricola (ORCID: https://orcid.org/0000-0002-4834-2187)
- Davide Margonato (ORCID: https://orcid.org/0000-0002-5817-6901)
- Federica Ilardi (ORCID: https://orcid.org/0000-0002-3885-5093)
- Giovanni Benfari (ORCID: https://orcid.org/0000-0002-5660-6162)
- Marco Matteo Ciccone (ORCID: https://orcid.org/0000-0002-5710-4228)
- Simona Sperlongano (ORCID: https://orcid.org/0000-0002-1699-5255)
- Martina Belli (ORCID: https://orcid.org/0000-0003-3648-9277)
- Saverio Muscoli (ORCID: https://orcid.org/0000-0002-4037-7561)
- Giulia Elena Mandoli (ORCID: https://orcid.org/0000-0002-3184-3006)
- Martina Setti (ORCID: https://orcid.org/0000-0002-3618-2833)
- Maria Concetta Pastore (ORCID: https://orcid.org/0000-0002-7223-141X)
- Alessandro Malagoli (ORCID: https://orcid.org/0000-0001-9119-4311)
- Alessandra Roccabruna
- Matteo Cameli (ORCID: https://orcid.org/0000-0003-3872-8964)
- Matteo Lisi (ORCID: https://orcid.org/0000-0003-4591-2030)
- Antonello D’Andrea
Institutions
- University of Siena (IT)
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- Vita-Salute San Raffaele University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Policlinico Umberto I (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- IRCCS Ospedale San Raffaele (IT)
- Policlinico Tor Vergata (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jaccas.2024.103087
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00