Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease
Increased LC3B expression and LC3B gene promoter hypermethylation may serve as biomarkers for progression of M. tb infection, while use of de-methylation agent may be a potential approach to host-directed immunotherapy in active TB disease.
Authors
- Chia-Cheng Tseng (ORCID: https://orcid.org/0000-0001-6613-0439)
- Sum-Yee Leung
- Chang‐Chun Hsiao (ORCID: https://orcid.org/0000-0002-7275-4675)
- Yi-Hsi Wang
- Tung-Ying Chao
- Jen-Chieh Chang
- Ying-Tang Fang
- Ting-Ya Wang
- Po‐Yuan Hsu
- Meng-Chih Lin
- Chiu-Ping Lee
- Chao-Chien Wu
- Yung-Che Chen
Institutions
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12931-025-03149-1
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Chang Gung Medical Foundation
- Ministry of Science and Technology, Taiwan
- National Science and Technology Council
- National Institutes of Health
- Kaohsiung Chang Gung Memorial Hospital
- National Institute of Allergy and Infectious Diseases