Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function
Our multi-omics MR analysis identified 15 RiboSis-related genes associated with cardiac risk, with 12 further validated through gene set enrichment analysis. These findings suggest a link between RiboSis and cardiac health, enhancing understanding of cardiac disease mechanisms.
Authors
- Lingbin He
- Ronghuai Shen
- Xianxi Huang (ORCID: https://orcid.org/0000-0001-5978-5031)
- Jiahang Yang
- Xinyi Li (ORCID: https://orcid.org/0000-0003-4605-1367)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9211-861X)
- Zhouwu Shu
- Shuxu Wei
- Xiaojia Lu
Institutions
- Guangdong Pharmaceutical University (CN)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13148-025-01850-y
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81