Is there diurnal variation in Magnesium neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?
Among acute cerebral ischemia patients, efficacy, safety, neuroprotective agent, and thrombolytic response outcomes were largely unmodified by witnessed onset during active versus inactive phase clock times. These findings suggest biologic wake-sleep state rather than chronologic clock time is the driver of known circadian rhythmicity in stroke course.
Authors
- Neal Rao (ORCID: https://orcid.org/0000-0001-7043-2675)
- Katherine T Mun
- Nerses Sanossian (ORCID: https://orcid.org/0000-0002-8218-9518)
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Robin Conwit (ORCID: https://orcid.org/0000-0001-7650-6698)
- Samuel J. Stratton (ORCID: https://orcid.org/0000-0002-2505-115X)
- Sidney Starkman (ORCID: https://orcid.org/0000-0003-4074-1076)
- Kristina Shkirkova (ORCID: https://orcid.org/0000-0002-9288-4258)
- Mersedeh Bahr Hosseini (ORCID: https://orcid.org/0000-0003-3049-4542)
- Fatima Pariona-Vargas (ORCID: https://orcid.org/0000-0002-1274-2015)
- May Kim‐Tenser (ORCID: https://orcid.org/0000-0003-0555-0661)
- Eng H. Lo (ORCID: https://orcid.org/0000-0002-9327-2915)
- Gilda Avila
- Marc Eckstein
- Jeffrey L Saver
- Latisha Sharma (ORCID: https://orcid.org/0000-0003-4132-2260)
Institutions
- University of Southern California (US)
- National Institutes of Health (US)
- University of California, Los Angeles (US)
- Louisiana State University in Shreveport (US)
- National Institute of Neurological Disorders and Stroke (US)
- Indiana University (US)
- Louisiana State University Health Sciences Center Shreveport (US)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108278
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke