Small extracellular vesicles enhance the survival of Sca-1+ cardiac stem cells against ROS-induced ischemic-reoxygenation injury in vitro
Conditioning Sca-1+/CSCs, an essential population in the postnatal heart, with sEVs rich in miRNA-21 robustly enhanced the proliferation, and synthesis phase of the cell cycle, and stabilized HIF-1α while alleviating oxidative stress and apoptosis. Such sEVs rich in miRNA-21-5p can be further used as a preconditioning tool to enhance endogenous Sca-1+/CSCs regeneration in response to IR injury.
Authors
- Samar Ibrahim (ORCID: https://orcid.org/0000-0001-5530-9521)
- Mona A Barkat
- Eman H Thabet (ORCID: https://orcid.org/0000-0003-3490-3825)
- Heba A Hamed
- Radwa A. Mehanna (ORCID: https://orcid.org/0000-0001-9048-4464)
- Nehal Adel Khalil (ORCID: https://orcid.org/0000-0001-9380-7425)
- Hagar Elkafrawy (ORCID: https://orcid.org/0000-0002-1591-1689)
- Marwa Kholief (ORCID: https://orcid.org/0000-0001-8776-5257)
- Ashraf K. Awaad (ORCID: https://orcid.org/0000-0001-8285-0188)
- Marwa M. Essawy (ORCID: https://orcid.org/0000-0002-4781-4293)
- Osama A. Mohammed (ORCID: https://orcid.org/0000-0001-9712-9609)
- A.N. Sallam
Institutions
- Alexandria University (EG)
Publication Details
- Journal
- Biological Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s40659-025-00593-7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alexandria University