Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function
We demonstrate a role for TTN-AS1-276 in facilitating alternative splicing of TTN and regulating sarcomere properties. This transcript could constitute a target for improving cardiac passive stiffness and diastolic function in conditions such as heart failure with preserved ejection fraction.
Authors
- Joakim Sandstedt (ORCID: https://orcid.org/0000-0002-6458-9550)
- Olof Gidlöf (ORCID: https://orcid.org/0000-0002-7402-3139)
- Pontus Nordenfelt (ORCID: https://orcid.org/0000-0002-9481-9951)
- Oscar André (ORCID: https://orcid.org/0000-0003-1732-9454)
- Kristina Vukušić (ORCID: https://orcid.org/0000-0002-4243-0565)
- Jane Synnergren (ORCID: https://orcid.org/0000-0003-4697-0590)
- Markus Johansson (ORCID: https://orcid.org/0000-0002-5134-4749)
- Yuan Li (ORCID: https://orcid.org/0000-0002-1929-5465)
- Juliana Assis Geraldo (ORCID: https://orcid.org/0000-0001-5995-8684)
- Selvi Celik (ORCID: https://orcid.org/0000-0001-7032-3444)
- Julia Martínez (ORCID: https://orcid.org/0000-0002-2272-9789)
- Ludvig Hyrefelt
- Tomasz Czuba (ORCID: https://orcid.org/0009-0001-0232-0425)
- J. Gustav Smith
Institutions
- Lund University (SE)
- University of Skövde (SE)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/cvr/cvaf037
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16