Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis
Combined inflammatory and hypoxic conditions in atherosclerotic plaques may markedly enhance procoagulant activity in macrophages and contribute to coronary thrombus formation following plaque disruption. Macrophage TF expression may be associated with glycolysis.
Authors
- Nobuyuki Oguri (ORCID: https://orcid.org/0009-0007-2064-0928)
- Yuichiro Z. Sato (ORCID: https://orcid.org/0000-0003-1171-2620)
- Yunosuke Matsuura (ORCID: https://orcid.org/0000-0003-2927-7284)
- Kensaku Nishihira (ORCID: https://orcid.org/0000-0002-1718-3830)
- Kazunari Maekawa (ORCID: https://orcid.org/0000-0002-5177-6242)
- Kinta Hatakeyama (ORCID: https://orcid.org/0000-0001-7729-1836)
- Toshihiro Gi (ORCID: https://orcid.org/0000-0003-1422-9044)
- Yujiro Asada (ORCID: https://orcid.org/0000-0001-5105-2159)
- Yoshihiro Komohara (ORCID: https://orcid.org/0000-0001-9723-0846)
- Atsushi Yamashita (ORCID: https://orcid.org/0000-0001-5487-7594)
- Eriko Nakamura (ORCID: https://orcid.org/0000-0002-3964-2831)
- Koichi Kaikita (ORCID: https://orcid.org/0000-0003-2962-8056)
- Yoshisato Shibata (ORCID: https://orcid.org/0009-0000-9053-3035)
- Yoichi Saito
- Sayaka Moriguchi‐Goto
Institutions
- University of Miyazaki (JP)
- National Cerebral and Cardiovascular Center (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1371/journal.pone.0316474
- Citations
- 3
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Japan Society for the Promotion of Science