Additional Bioactive Silvestrol Analogs from the Roots of <i>Aglaia perviridis</i> Collected in Vietnam

The tropical plant <i>Aglaia perviridis</i> is known to produce cyclopenta[<i>b</i>]benzofuran and other types of rocaglate derivatives including silvestrol (<b>3</b>) and 5‴-episilvestrol (<b>4</b>) that are of current pharmacological interest. In the present work, further investigation of <i>A. perviridis</i> roots collected in Vietnam has yielded two new rocaglate acetonide derivatives (<b>1</b> and <b>2</b>) and a known pentanor-3,4-<i>seco</i>-dammarane triterpenoid (<b>7</b>) found for the first time as a natural product, in addition to four known rocaglates (<b>3</b>-<b>6</b>). The structures of compounds <b>1</b> and <b>2</b> were confirmed by partial synthesis experiments, and their potential occurrence as extraction artifacts was investigated by targeted selective ion monitoring using UHPLC-MS. All compounds obtained were evaluated against a panel of four human cancer cell lines, in which the six rocaglate derivatives (<b>1</b>-<b>6</b>) tested all showed submicromolar potencies.