Impact of zinc on hepatocellular carcinoma cell behavior and metallothionein expression: Insights from preclinical models
Zn supplementation influences key cellular behaviors in a dose-dependent manner and upregulates the expression of MT family genes, which may have tumor-suppressive properties, in vitro an in vivo models. Future research should investigate the prognostic implications of Zn supplementation as part of a comprehensive therapeutic strategy for HCC patients.
Authors
- María Bermúdez-Ramos (ORCID: https://orcid.org/0000-0002-5516-3902)
- Beatriz Mínguez (ORCID: https://orcid.org/0000-0002-7276-9666)
- Elena Vargas‐Accarino (ORCID: https://orcid.org/0000-0002-2521-0368)
- Mónica Higuera (ORCID: https://orcid.org/0000-0002-3999-9603)
- María Torrens
- María Teresa Salcedo
- Agnès Soriano-Varela (ORCID: https://orcid.org/0009-0006-1464-5055)
Institutions
- Hebron University (PS)
- Universitat Autònoma de Barcelona (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.biopha.2025.117918
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12