The association between non-depolarizing neuromuscular blockade agents and survival to discharge in dogs undergoing mechanical ventilation: a multi-center retrospective study of 227 dogs (2010–2020)
This study revealed no statistical significance between NMBA use and survival or complications. However, dogs in the NMBA group likely had more severe hypoxemia than the non-NMBA group, as indicated by their lower PF ratios and SPO<sub>2</sub> values prior to initiation of mechanical ventilation. The similarities in survival rate between the NMBA and non-NMBA patient populations, despite higher severity of respiratory pathology in the NMBA group, may suggest a potential therapeutic benefit to NMBA use for MV patients. Further investigation into the use of NMBAs in patients undergoing MV are warranted.
Authors
- Rebecca Walton (ORCID: https://orcid.org/0000-0001-5438-3017)
- April E. Blong (ORCID: https://orcid.org/0000-0001-8003-6916)
- Lena Ngo (ORCID: https://orcid.org/0000-0001-9376-9692)
- Jacob Wolf (ORCID: https://orcid.org/0000-0002-5116-4043)
- Jonathan P. Mochel (ORCID: https://orcid.org/0000-0002-0997-3111)
- Nyssa A. Levy (ORCID: https://orcid.org/0000-0003-4101-3767)
- Britt A. L. Thevelein
- Tasia M. Ludwik (ORCID: https://orcid.org/0000-0001-6152-9897)
- Jiazhang Cai (ORCID: https://orcid.org/0009-0002-0267-9726)
Institutions
- West Los Angeles College (US)
- University of Minnesota (US)
- University of Georgia (US)
- Iowa State University (US)
- University of Florida (US)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fvets.2025.1539138
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00