Antagonizing the S1P-S1P3 Axis as a Promising Anti-Angiogenic Strategy
These findings highlight S1PR3 as a critical regulator of angiogenesis and posit its targeting as a novel anti-angiogenic strategy, particularly for aggressive, S1P-secreting tumors with pronounced metastatic potential and an acidic microenvironment.
Authors
- Beatrice Ulloa Severino (ORCID: https://orcid.org/0000-0002-3887-8869)
- Maria Veronica Lipreri (ORCID: https://orcid.org/0000-0002-5634-2208)
- Antonia Scognamiglio (ORCID: https://orcid.org/0000-0002-4282-2788)
- Nicola Baldini (ORCID: https://orcid.org/0000-0003-2228-3833)
- Angela Corvino (ORCID: https://orcid.org/0000-0002-0617-156X)
- Sofia Avnet (ORCID: https://orcid.org/0000-0002-7843-0591)
- Margherita Cortini (ORCID: https://orcid.org/0000-0002-8151-8105)
- Emi Mizushima
Institutions
- Sapporo Medical University (JP)
- Istituto Ortopedico Rizzoli (IT)
- University of Naples Federico II (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Metabolites
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3390/metabo15030178
- Citations
- 4
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Fondazione Italiana per la Ricerca sul Cancro