Activated Microglia Mediate the Motor Neuron‐, Synaptic Denervation‐ and Muscle Wasting‐Changes in Burn Injured Mice
Microglia-mediated inflammatory responses play pivotal role in MNL as decrease of inflammatory responses improved MNL; α7AChR stimulation also mitigated synaptic denervation and MW changes of BI. α7AChRs have a role in spinal homeostasis even in uninjured state.
Authors
- J. A. Jeevendra Martyn (ORCID: https://orcid.org/0000-0001-9618-4526)
- William R. Kem (ORCID: https://orcid.org/0000-0001-8492-3969)
- Haobo Li (ORCID: https://orcid.org/0000-0002-5660-7835)
- Jingyuan Chen (ORCID: https://orcid.org/0000-0001-8691-883X)
- Fei Xie (ORCID: https://orcid.org/0000-0002-7218-5222)
- Yoshinori Kitagawa (ORCID: https://orcid.org/0000-0002-3275-3336)
- Shingo Yasuhara
- Zerong You
Institutions
- Shriners Hospitals for Children - Erie (US)
- Harvard University (US)
- University of Electronic Science and Technology of China (CN)
- Sun Yat-sen University (CN)
- University of Florida (US)
- Massachusetts General Hospital (US)
- Sichuan Cancer Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Tottori University (JP)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1002/jcsm.13755
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Shriners Hospitals for Children
- National Institutes of Health