Asptertides A–H, C<sub>13</sub>‐Polyketides From a Marine‐Derived <i>Aspergillus terreus</i>
In the present study, 11 C<sub>13</sub>-polyketides comprising a monocyclic skeleton of an aromatic (1-6 and 11) or a cyclohexanone moiety (7) and an oxygenated bicyclic nucleus (8-10) were isolated from a mutated strain of endophytic fungus Aspergillus terreus RA2905. Five pairs of enantiomers (2a/b-5a/b and 7a/b) were achieved by chiral-phase HPLC separation. The structures of previously unreported asptertides A-H (1-8) were determined by analysis of the spectroscopic data and electronic circular dichroism (ECD) calculations. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging bioassays revealed that some compounds showed moderate antioxidant effects, with IC<sub>50</sub> values ranging from 13.7 to 35.6 µM.
Authors
- Chu-Hong Fang (ORCID: https://orcid.org/0000-0002-2978-9530)
- Zhi‐Pu Yu
- Jin‐Hai Yu (ORCID: https://orcid.org/0000-0002-4104-3168)
- Jian‐Min Yue (ORCID: https://orcid.org/0000-0002-4053-4870)
- Changchun Wang (ORCID: https://orcid.org/0000-0003-3183-2160)
- Bin Zhou (ORCID: https://orcid.org/0000-0001-9000-5320)
- Xiangyu Liu (ORCID: https://orcid.org/0009-0008-2673-4367)
- Yanli Xu (ORCID: https://orcid.org/0009-0006-4945-6334)
- Ying Li
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Advanced Research Institute (US)
- Drug Discovery Laboratory (Norway) (NO)
- Shandong First Medical University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1002/cbdv.202500494
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00