Knockdown of <scp>SESN2</scp> Exacerbates Cerebral Ischemia–Reperfusion Injury Through Enhancing Glycolysis via the <scp>mTOR</scp>/<scp>HIF</scp>‐1α Pathway
Knockdown of SESN2 in MCAO mice increased the expression of the p-mTOR/HIF-1α pathway, which increased glycolysis and lactate levels and, in turn, affected IS injury.
Authors
- Ran Chen (ORCID: https://orcid.org/0009-0002-6989-4076)
- Lijuan Gu (ORCID: https://orcid.org/0000-0003-1928-8772)
- Hua Zhu (ORCID: https://orcid.org/0000-0002-3878-2672)
- Xiaoxing Xiong (ORCID: https://orcid.org/0000-0001-6983-8547)
- Yonggang Zhang (ORCID: https://orcid.org/0000-0002-5251-3815)
- Zhi‐Hui Wang (ORCID: https://orcid.org/0000-0001-7815-3857)
- Mohammad Rohul Amin (ORCID: https://orcid.org/0009-0007-9025-5443)
- Yingao Huang
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70314
- Citations
- 5
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03