Exploring the Therapeutic Mechanism of Xinbao Pill in Brain Injury After Cardiopulmonary Resuscitation Based on Network Pharmacology, Metabolomics, and Experimental Verification
Our study first determined that XBP might be an underlying anti-PBI formula, which also deciphered the potential MOAs of XBP against PBI by a network pharmacology approach combined with in vivo and in vitro experimental validation.
Authors
- Banghan Ding (ORCID: https://orcid.org/0000-0002-1555-5055)
- Ruifeng Zeng (ORCID: https://orcid.org/0000-0002-4209-2930)
- Jiansong Fang (ORCID: https://orcid.org/0000-0002-6998-5384)
- Zunjiang Li
- Linling Liu
- Baijian Chen
- Yong Gu (ORCID: https://orcid.org/0000-0002-4444-9382)
- Qihui Wu (ORCID: https://orcid.org/0000-0001-7154-7765)
- Dongli Li (ORCID: https://orcid.org/0000-0002-5351-8458)
- Zeyu Ding
- Xing Sun
- Qiqi Wu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Key Laboratory of Guangdong Province (CN)
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70297
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Natural Science Foundation of Guangdong Province
- Science and Technology Planning Project of Guangdong Province