Short‐chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile
In MS, plasma PA/AA and BA/AA ratios are unbalanced, promoting an environment that could be boosting the mechanisms underlying the pathogenesis of the disease. Since we have found statistical significant associations with the EDSS and the number of T2 lesions, but not with the number of relapses or gadolinium enhancing lesions, PA/AA and BA/AA ratios could be more associated with those mechanisms of the disease related to the neurodegenerative processes than those related with the activity of the disease.
Authors
- María Inmaculada Domínguez‐Mozo (ORCID: https://orcid.org/0000-0001-9236-5717)
- Ignacio Casanova‐Peño
- Yolanda Aladro (ORCID: https://orcid.org/0000-0001-9459-5452)
- Inés González‐Suarez (ORCID: https://orcid.org/0000-0002-9897-0771)
- Roberto Álvarez‐Lafuente (ORCID: https://orcid.org/0000-0002-3132-1486)
- Xavier Montalbán (ORCID: https://orcid.org/0000-0002-0098-9918)
- Noelia Villarrubia (ORCID: https://orcid.org/0000-0002-2114-8632)
- José L. Luque-García (ORCID: https://orcid.org/0000-0001-6273-0349)
- María Luisa Martínez‐Ginés (ORCID: https://orcid.org/0009-0005-1264-2793)
- María Angel Garcia‐Martinez
- Lucienne Costa‐Frossard (ORCID: https://orcid.org/0000-0002-6512-4413)
- Estefanía García‐Calvo (ORCID: https://orcid.org/0000-0002-3907-0212)
- Belén Pilo
- Luisa María Villar (ORCID: https://orcid.org/0000-0002-9067-3668)
- José Manuel García‐Domínguez (ORCID: https://orcid.org/0000-0002-5205-3652)
- Manuel Comabella (ORCID: https://orcid.org/0000-0002-2373-6657)
- Rafael Arroyo
- Andrés Machuca‐Marcos
- Daniel López‐Mecández
Institutions
- Universidad Complutense de Madrid (ES)
- Universitat Autònoma de Barcelona (ES)
- Universidad Francisco de Vitoria (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario de Torrejón (ES)
- Spanish Multiple Sclerosis Network (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital Universitario de Getafe (ES)
- Hospital Universitario Quirónsalud Madrid (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/acn3.52259
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Fundación Lair
- European Regional Development Fund