Glial Alterations in the Glutamatergic and GABAergic Signalling Pathways in a Mouse Model of Lafora Disease, a Severe Form of Progressive Myoclonus Epilepsy
The observed upregulation of glutamatergic receptor subunits likely amplifies excitatory glutamatergic signalling, whereas the increased expression of GAT1 may reduce the inhibitory GABAergic tone. These changes contribute to the characteristic hyperexcitability of LD.
Authors
- Ángela Campos‐Rodríguez
- Pascual Sanz (ORCID: https://orcid.org/0000-0002-2399-4103)
- Rosa Viana (ORCID: https://orcid.org/0000-0002-0036-0669)
- Teresa Rubio (ORCID: https://orcid.org/0000-0003-0843-528X)
Institutions
- Instituto de Salud Carlos III (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto de Biomedicina de Valencia (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1111/nan.70009
- Citations
- 1
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Fundació la Marató de TV3
- Generalitat Valenciana
- Ministerio de Ciencia y Tecnología
- National Institutes of Health