[Dihydroartemisinin enhances doxorubicin-induced apoptosis of triple negative breast cancer cells by negatively regulating the STAT3/HIF-1α pathway].
DHA combined with DOX produces significantly enhanced effects for inhibiting cell proliferation and inducing apoptosis in MDA-MB-231 cells possibly as result of DHA-mediated negative regulation of the STAT3/HIF-1α pathway.
Authors
- Xin Zhou (ORCID: https://orcid.org/0000-0002-1407-7952)
- Di Chen (ORCID: https://orcid.org/0000-0002-2332-6666)
- Yuxin Chen (ORCID: https://orcid.org/0000-0001-5955-687X)
- Ruixuan Wang (ORCID: https://orcid.org/0000-0002-6238-6987)
- Ying Lü (ORCID: https://orcid.org/0000-0002-9976-6262)
- Yixin Guo (ORCID: https://orcid.org/0009-0009-4211-0519)
- Xiaohui Wu (ORCID: https://orcid.org/0000-0002-0983-0962)
- Yirong Zhang
Institutions
- Xi'an Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-02-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.02.06
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article