Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in MAPT, the microtubule-associated protein tau gene, give rise to cases of FTD and parkinsonism linked to chromosome 17. These individuals develop abundant filamentous tau inclusions in brain cells in the absence of β-amyloid deposits. Here, we used cryo-electron microscopy to determine the structures of tau filaments from the brains of human MAPT mutants V337M and R406W. Both amino acid substitutions gave rise to tau filaments with the Alzheimer fold, which consisted of paired helical filaments in all V337M and R406W cases and of straight filaments in two V337M cases. We also identified another assembly of the Alzheimer fold into triple tau filaments in a V337M case. Filaments assembled from recombinant tau (297-391) with substitution V337M had the Alzheimer fold and showed an increased rate of assembly.
Authors
- Marika Bogdani (ORCID: https://orcid.org/0000-0002-4677-7523)
- Catarina Franco (ORCID: https://orcid.org/0000-0003-2288-1518)
- Jill R. Murrell (ORCID: https://orcid.org/0000-0002-1885-8385)
- Alexey G. Murzin
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Sew‐Yeu Peak‐Chew (ORCID: https://orcid.org/0000-0002-7602-6384)
- Michel Goedert (ORCID: https://orcid.org/0000-0002-5214-7886)
- Bernardino Ghetti (ORCID: https://orcid.org/0000-0002-1842-8019)
- Chao Qi (ORCID: https://orcid.org/0000-0003-1277-0363)
- Patrick W. Cullinane (ORCID: https://orcid.org/0000-0002-4360-2680)
- Sofia Lövestam (ORCID: https://orcid.org/0000-0002-2152-1476)
- Sjors H. W. Scheres (ORCID: https://orcid.org/0000-0002-0462-6540)
- Zane Jaunmuktane (ORCID: https://orcid.org/0000-0001-7738-8881)
- Thomas D. Bird
Institutions
- Children's Hospital of Philadelphia (US)
- MRC Laboratory of Molecular Biology (GB)
- King's College London (GB)
- University of Washington (US)
- Hospital of the University of Pennsylvania (US)
- VA Puget Sound Health Care System (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Nature Structural & Molecular Biology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1038/s41594-025-01498-5
- Citations
- 13
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.14