CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma

The prevention and precise treatment of early-stage lung adenocarcinoma (LUAD) characterized by small nodules (stage IA) remains a significant challenge for clinicians, which is due largely to the limited understanding of the oncogenic mechanisms spanning from preneoplasia to invasive adenocarcinoma. Our study highlights the pivotal role of cancer cells exhibiting high expression of centromere protein F (CENPF), driven by TP53 mutations, which become increasingly prevalent during the transition from preneoplasia to invasive LUAD. Biologically, cancer cells (CENPF+) exhibited robust proliferative and stem-like capabilities, thereby propelling the malignant progression of early-stage LUAD. Clinically, autoantibodies against CENPF in the serum and elevated cancer cells (CENPF+) in tissue correlated positively with the progression of early-stage LUAD, especially those in stage IA. Our findings suggest that cancer cells (CENPF+) play a central role in orchestrating the malignant evolution of LUAD and hold potential as a novel biomarker for early-stage detection and management of the disease.

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Publication Details

Journal
Oncogenesis
Published
2025-03-05
DOI
https://doi.org/10.1038/s41389-025-00546-5
Citations
4
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
3.75
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article

CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma

Wenchen Wang, Tao Jiang, Ying Sun, Xiaohong Ji et al.
4 citations
Oncogenesis
Cancer Genomics and Diagnostics
3.75
article

CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma

Wenchen Wang, Tao Jiang, Ying Sun, Xiaohong Ji, Lintao Jia, Miaomiao Wen, Yongfu Ma, Yahui Tian, Yanlu Xiong, Shaowei Xin, Xiaoyan Li, Yang Liu, Yong Han, Jiao Zhang, Jie Yang, Jinbo Zhao, Jie Lei, Zitong Wan, Jianfei Zhu
article en
4 citations

Abstract

The prevention and precise treatment of early-stage lung adenocarcinoma (LUAD) characterized by small nodules (stage IA) remains a significant challenge for clinicians, which is due largely to the limited understanding of the oncogenic mechanisms spanning from preneoplasia to invasive adenocarcinoma. Our study highlights the pivotal role of cancer cells exhibiting high expression of centromere protein F (CENPF), driven by TP53 mutations, which become increasingly prevalent during the transition from preneoplasia to invasive LUAD. Biologically, cancer cells (CENPF+) exhibited robust proliferative and stem-like capabilities, thereby propelling the malignant progression of early-stage LUAD. Clinically, autoantibodies against CENPF in the serum and elevated cancer cells (CENPF+) in tissue correlated positively with the progression of early-stage LUAD, especially those in stage IA. Our findings suggest that cancer cells (CENPF+) play a central role in orchestrating the malignant evolution of LUAD and hold potential as a novel biomarker for early-stage detection and management of the disease.

OncogenesisVol. 14(1)
Shanxi Medical University (CN), Chinese PLA General Hospital (CN), Shaanxi Provincial People's Hospital (CN), Air Force General Hospital PLA (CN), Tang Du Hospital (CN), Shanxi Provincial People’s Hospital (CN), Air Force Medical University (CN)
Good health and well-being
Openalex Percentile: Top 8%
Cancer Genomics and Diagnostics
3.75
DOIOpen Access PDFOpenAlex
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