Comparison of Proton Versus Photon SBRT for Treatment of Spinal Metastases Using Variable RBE Models
We report the first dosimetric analysis of proton SBRT for spine metastasis using variable RBE dose models. Compared to photon SBRT, IMPT may provide improved target coverage and better spare adjacent OARs, though fixed RBE models can underestimate the maximum dose to adjacent OARs. Future prospective studies are needed to validate these results.
Authors
- Daniel Lubelski (ORCID: https://orcid.org/0000-0002-9403-9509)
- Kristin J. Redmond (ORCID: https://orcid.org/0000-0003-3442-4613)
- Majid Khan (ORCID: https://orcid.org/0000-0002-3807-1387)
- Lawrence Richard Kleinberg (ORCID: https://orcid.org/0000-0003-2473-2305)
- Nicholas Theodore (ORCID: https://orcid.org/0000-0001-5355-2683)
- T. Hooker
- M.C. LeCompte (ORCID: https://orcid.org/0000-0002-3116-007X)
- Ali Bydon (ORCID: https://orcid.org/0000-0002-3058-1470)
- Khaled M. Kebaish (ORCID: https://orcid.org/0000-0002-1235-6202)
- Heng Li (ORCID: https://orcid.org/0000-0002-6666-0277)
- Hao Chen (ORCID: https://orcid.org/0000-0002-6282-0237)
- Sang Hong Lee (ORCID: https://orcid.org/0000-0002-2258-1147)
- S. Shaaban (ORCID: https://orcid.org/0000-0002-8443-5655)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.ijpt.2025.100743
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00