Natural flavonoid Orientin restricts 5-Fluorouracil induced cancer stem cells mediated angiogenesis by regulating HIF1α and VEGFA in colorectal cancer
This novel treatment strategy of "Orientin with 5FU" is likely to improve the efficiency of conventional chemotherapy and may suppress disease recurrence in colorectal cancer by limiting CSC mediated angiogenesis.
Authors
- Souradeep Biswas (ORCID: https://orcid.org/0000-0003-1930-1842)
- Rituparna Ghosh
- Rupali Sarkar (ORCID: https://orcid.org/0000-0002-3297-3208)
- Shampa Pakhira
- Mrinmoyee Mondal
- Priya Samanta
- Subhadip Hajra (ORCID: https://orcid.org/0000-0002-1715-4722)
- Arijit Bhowmik (ORCID: https://orcid.org/0000-0001-8321-9996)
- Prosenjit Saha
Institutions
- Chittaranjan National Cancer Institute (IN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s10020-024-01032-1
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Indian Council of Medical Research
- Science and Engineering Research Board