Evaluation of Lipoxygenase Inhibitory Potential of the Ethanol Fraction from Star Fruit (Averrhoa carambola L.) Leaves Sourced from Assam.

Averrhoa carambola L. leaves have long been utilized in traditional medicine. This study aimed to assess theanti-inflammatory potential of A. carambola L. leaf extracts through a lipoxygenase inhibition assay, focusingon the ethanol fraction derived from leaves collected in Ahomgaon, Assam. The extraction process was carriedout using the Soxhlet method, initially with petroleum ether, followed by 95% ethanol. The ethanol fraction wasthen evaluated for its lipoxygenase inhibitory activity using linoleic acid as the substrate, while its total flavonoidand total phenol contents were also quantified. The correlation between IC50 values and the total flavonoid andtotal phenol contents in the ethanol fraction was analyzed. Results showed that the ethanol fraction inhibitedlipoxygenase enzyme activity, with an IC50 value of 96.86 µg/mL.