De novo abnormalities identified by fluorescence in situ hybridization during follow-up confer poor prognosis in Chinese multiple myeloma
Re-evaluation of cytogenetic characteristics by serial FISH tests is important in MM patients. <i>De novo</i> FISH abnormalities during follow-up are adverse prognostic factors, especially when ≥2 new FISH anomalies and acquired new abnormalities within 31 months since diagnosis are presented, and the presence of ≥2 HRA during the disease process are associated with poor survival in Chinese MM patients.
Authors
- Jin Lu (ORCID: https://orcid.org/0000-0001-5004-2741)
- Shu Kong
- Xiao‐Jun Huang (ORCID: https://orcid.org/0000-0002-2145-6643)
- Lu Gao (ORCID: https://orcid.org/0000-0001-7534-7891)
- Li Ye (ORCID: https://orcid.org/0000-0002-9246-5520)
- Qing Liu (ORCID: https://orcid.org/0000-0001-5286-4423)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-9330-0728)
- Shumin Chen (ORCID: https://orcid.org/0000-0003-0687-8212)
- Yue‐Yun Lai
- Ying Chang (ORCID: https://orcid.org/0000-0002-3792-7016)
- Lin Feng (ORCID: https://orcid.org/0000-0002-0663-8430)
- Wenjie Song (ORCID: https://orcid.org/0000-0001-8196-2372)
- Yang Liu (ORCID: https://orcid.org/0000-0002-8471-8460)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fmed.2025.1536825
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00