Post-stem cell transplant maintenance for pediatric acute leukemias: insights from a Brazilian institution with a Latin American perspective
Post-HSCT maintenance therapy is feasible in resource-limited settings and may improve survival outcomes. Strategies like hypomethylating agents with venetoclax in T-ALL and post-HSCT blinatumomab in B-ALL show potential benefits. Challenges include drug access and standardizing protocols. Further trials are needed to validate these findings in low- and middle-income countries.
Authors
- Roseane Vasconcelos Gouveia
- Valéria Cortez Ginani
- Anna Beatriz Willemes Batalha
- Carla Nolasco Monteiro Breviglieri (ORCID: https://orcid.org/0000-0002-6089-5526)
- Adriana Seber (ORCID: https://orcid.org/0000-0003-4578-9423)
- Juliana Francielle Marques
- Edna Harumi Goto
- Marcia Puato Vieira Pupim
- Milena Oliveira
- Camila Noronha Santos
- Gabriella Sayuri de Alencar
Institutions
- Support group for adolescents and children with cancer (BR)
- Hospital Samaritano de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fonc.2025.1540158
- Citations
- 3
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 5.64