Oxidative stress and inflammation combine to exacerbate cochlear damage and sensorineural hearing loss in C57BL/6 mice
These findings indicate that the interaction between oxidative stress and inflammation may exacerbate cochlear damage and contribute to hearing loss, potentially through the activation of necroptosis and ferroptosis pathways. Our results may identify potential therapeutic targets for the management of SNHL.
Authors
- Yuyan Chen (ORCID: https://orcid.org/0000-0002-2894-1430)
- Jie Cui (ORCID: https://orcid.org/0000-0001-9391-6744)
- H. Chen (ORCID: https://orcid.org/0000-0003-1514-7016)
- Qi Li (ORCID: https://orcid.org/0000-0002-9144-148X)
- Yu Liu
- Jinyuan Cao
- Zhongwu Su (ORCID: https://orcid.org/0000-0003-0758-9308)
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fnins.2025.1563428
- Citations
- 2
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 2.93