Palladium-Catalyzed Sonogashira Cross-Couplings of (Hetero)Aryl Fluorosulfates
The palladium-catalyzed Sonogashira cross-coupling of (hetero)aryl fluorosulfates and terminal alkynes, featuring a synthetically useful scope and yields, is reported herein. Such transformations involving a diversity of (hetero)aryl fluorosulfate coupling partners, including chemoselective examples where contending chloro functionalities are present, are achieved using a DPPF/[Pd(cinnamyl)Cl]<sub>2</sub> catalyst system without the requirement of a copper additive.
Authors
- Maximilian Lübbesmeyer
- Philipp M. Holstein (ORCID: https://orcid.org/0000-0001-6952-7706)
- Mark Stradiotto (ORCID: https://orcid.org/0000-0002-6913-5160)
- Mark J. Ford
- Sherif J. Kaldas (ORCID: https://orcid.org/0000-0003-2497-1963)
- Giulio Volpin (ORCID: https://orcid.org/0000-0002-4348-9075)
- Nicolas Guimond (ORCID: https://orcid.org/0000-0001-5258-2557)
- Kathleen M. Morrison
Institutions
- Dalhousie University (CA)
- Bayer (Germany) (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c00419
- Citations
- 2
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Bayer
- Dalhousie University
- Killam Trusts
- Natural Sciences and Engineering Research Council of Canada