tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway
tRF-5028c upregulation impaired trophoblast function to facilitate RSA development by directly targeting CRKL-mediated Rap1 pathway. The findings provide the first evidence of tsRNA dysregulation in RSA pathogenesis and lay a foundation for potential targeted therapies.
Authors
- Xiaoyan Ai (ORCID: https://orcid.org/0000-0002-8329-4272)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3087-4767)
- Xiangpeng Xiong
- Jiaying Lin (ORCID: https://orcid.org/0000-0002-1473-5636)
- Jialyu Huang (ORCID: https://orcid.org/0000-0002-2629-3986)
- Lingling Huang (ORCID: https://orcid.org/0009-0008-8237-3404)
- Lu Wang (ORCID: https://orcid.org/0000-0001-7505-7894)
- Shuang Wang (ORCID: https://orcid.org/0000-0001-9275-5299)
- Jiawei Wang (ORCID: https://orcid.org/0000-0003-3231-0305)
- Fang Zheng (ORCID: https://orcid.org/0000-0002-2024-2424)
- Chaoyi Xiong
- R. Jiang (ORCID: https://orcid.org/0009-0002-3001-764X)
Institutions
- University of Science and Technology of China (CN)
- Nanchang University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s11658-025-00706-w
- Citations
- 6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 12.34
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province