Psychosomatic - psychotherapeutic treatment of stress-related disorders impacts the sphingolipid metabolism towards increased sphingosine and sphingosine-1-phosphate levels
Psychosomatic - psychotherapeutic treatment was associated with a reduction in specific ceramide ratios and an increase in sphingosine and S1P levels potentially resulting from increased activity of sphingolipid metabolizing enzymes. Stress-induced mental disorders might be associated with disturbed sphingolipid levels that seem to be balanced during psychosomatic treatment. This study offers a further piece of evidence that the sphingolipid metabolism could be involved in the pathophysiology of stress-induced disorders, and its analysis could be helpful for treatment monitoring.
Authors
- Burkhard Kleuser (ORCID: https://orcid.org/0000-0002-1888-9595)
- Franziska Werner (ORCID: https://orcid.org/0000-0002-1502-2259)
- Caterina Schug (ORCID: https://orcid.org/0009-0003-1936-3039)
- Eva Schäflein (ORCID: https://orcid.org/0000-0003-2380-4848)
- Fabian Schumacher (ORCID: https://orcid.org/0000-0001-8703-3275)
- Werner Adler (ORCID: https://orcid.org/0000-0001-9791-5407)
- Cosima Rhein (ORCID: https://orcid.org/0000-0002-3010-2169)
- Eva Morawa (ORCID: https://orcid.org/0000-0002-2885-7503)
- Johannes Kornhuber (ORCID: https://orcid.org/0000-0002-8096-3987)
- Yeşim Erim (ORCID: https://orcid.org/0000-0002-8215-1798)
- Christiane Mühle (ORCID: https://orcid.org/0000-0001-7517-9154)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1007/s00406-025-01985-2
- Citations
- 4
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Friedrich-Alexander-Universität Erlangen-Nürnberg
- Universitätsklinikum Erlangen