Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons
Our findings suggest that 2 weeks of exposure to LPS is not sufficient to cause dopaminergic neuronal loss in LRRK2 G2019S KI mice but rather results in increased astrocyte activation, which can be ameliorated by caffeine.
Authors
- Rachit Bakshi (ORCID: https://orcid.org/0000-0002-8531-7941)
- Michael A. Schwarzschild (ORCID: https://orcid.org/0000-0001-6019-8280)
- Grace F. Crotty (ORCID: https://orcid.org/0000-0002-8106-7842)
- Hoang Kieu Chi Ngo (ORCID: https://orcid.org/0000-0003-2151-5401)
- Hoang Le (ORCID: https://orcid.org/0000-0001-8427-3230)
- Samuel J. Ayer
- Akriti Srivastava
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12868-025-00939-7
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Farmer Family Foundation
- National Institutes of Health