KLF5 enhances CXCL12 transcription in adipose-derived stem cells to promote endothelial progenitor cells neovascularization and accelerate diabetic wound healing
Our findings underscore the pivotal role of KLF5 in enhancing CXCL12 transcription within ADSCs, thereby facilitating EPC-mediated neovascularization and improving diabetic wound healing. Additionally, KLF5 emerges as a promising therapeutic target for accelerating tissue repair in diabetic wounds.
Authors
- Xuejun Ni
- Tao Huang (ORCID: https://orcid.org/0000-0001-9004-6130)
- Beichen Cai (ORCID: https://orcid.org/0000-0002-6648-7873)
- Xuefeng Hu (ORCID: https://orcid.org/0000-0001-9683-3506)
- Chensheng Lin (ORCID: https://orcid.org/0000-0001-7898-6648)
- Nating Xu
- Xiuying Shan (ORCID: https://orcid.org/0000-0002-3718-5075)
- Ruonan Ke (ORCID: https://orcid.org/0009-0001-5039-2685)
- Lu Chen (ORCID: https://orcid.org/0000-0003-2906-2507)
- Qian Lin (ORCID: https://orcid.org/0000-0002-1513-6993)
- Xi Zheng (ORCID: https://orcid.org/0009-0001-7278-2553)
- Yunjia Xie
- Xiaofen Wan
- Biao Wang (ORCID: https://orcid.org/0000-0001-6253-2713)
Institutions
- Fujian Normal University (CN)
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s11658-025-00702-0
- Citations
- 8
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Fujian Provincial Finance Department
- Natural Science Foundation of Fujian Province