Proof of concept pilot study to assess the utility of magnetic resonance extra-cellular volume quantification to diagnose advanced liver disease in people with Cystic Fibrosis
Liver MRI ECV quantification was feasible in adults with CF with no significant difference in results between 1.5T and 3T obtained images suggesting applicability across different types of MRI scanner. A higher MRI ECV was demonstrated in CF participants with cirrhosis suggesting potential utility as a diagnostic tool for those with advanced CFLD. Further evaluation in larger cohorts is warranted.
Authors
- Josephine H. Naish (ORCID: https://orcid.org/0000-0002-8980-8924)
- Velauthan Rudralingam
- Jennifer A. Scott (ORCID: https://orcid.org/0000-0001-6112-2093)
- Daniel Tewkesbury (ORCID: https://orcid.org/0000-0002-2763-8990)
- Karen Piper Hanley (ORCID: https://orcid.org/0000-0001-9473-9647)
- Andrew Jones (ORCID: https://orcid.org/0000-0003-3232-1055)
- Varinder Singh Athwal (ORCID: https://orcid.org/0000-0002-1684-721X)
- Sue Liong
- R.J. Bright-Thomas
Institutions
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1371/journal.pone.0318085
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00