Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo
Our findings suggest that microglia may not be able to control cryptococcal CNS infection and that active capsular production and release may contribute to the progression and persistence of cerebral cryptococcosis.
Authors
- Fahong Yu (ORCID: https://orcid.org/0000-0002-9342-6419)
- Luis R. Martinez (ORCID: https://orcid.org/0000-0001-6372-6501)
- Luz M. Porras
- Raddy L. Ramos (ORCID: https://orcid.org/0000-0001-7588-5729)
- Paola Giusti‐Rodríguez (ORCID: https://orcid.org/0000-0002-1921-1305)
- Vanessa Enriquez
- Claudia Charles‐Niño (ORCID: https://orcid.org/0000-0002-0991-9174)
- Karina Alviña (ORCID: https://orcid.org/0000-0002-8369-0953)
- Melissa E. Munzen
- Michael R. Dores
Institutions
- Hofstra University (US)
- University of Florida (US)
- New York Institute of Technology (US)
- Université Bourgogne Franche-Comté (FR)
- Florida College (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12974-025-03384-9
- Citations
- 7
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- National Institute of Mental Health
- National Institute on Deafness and Other Communication Disorders
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research