NR4A1 Acts as a Novel Regulator of Platelet Activation and Thrombus Formation
We provide the first evidence that nuclear receptor NR4A1 negatively regulates platelet activation and thrombus formation. NR4A1 may serve as a novel therapeutic target for managing thrombosis-based cardiovascular diseases, especially with hypercholesterolemia.
Authors
- Alex F. Chen (ORCID: https://orcid.org/0000-0002-9792-0916)
- Liuhua Hu (ORCID: https://orcid.org/0000-0002-3203-7161)
- Bin Sheng (ORCID: https://orcid.org/0000-0001-8678-2784)
- Peiliang Fang
- Yong Ji (ORCID: https://orcid.org/0000-0003-2650-5747)
- Jingjing Fa (ORCID: https://orcid.org/0000-0001-6933-3717)
- Xiao Hua Guo (ORCID: https://orcid.org/0009-0008-8114-3965)
- Fangyuan Zhong
- Xingwen Da (ORCID: https://orcid.org/0000-0002-4639-0628)
- Jianfeng Shi (ORCID: https://orcid.org/0009-0000-4866-9449)
- Ancai Yuan (ORCID: https://orcid.org/0000-0002-4006-7897)
- Yichao Zhao (ORCID: https://orcid.org/0000-0001-8784-5361)
- Lei Chen (ORCID: https://orcid.org/0000-0001-7864-8649)
- Jun Pu (ORCID: https://orcid.org/0000-0003-2240-5108)
- Junling Liu (ORCID: https://orcid.org/0000-0002-2510-790X)
- Zhaoyan Li (ORCID: https://orcid.org/0000-0002-7381-1539)
- Gaoxiang Li (ORCID: https://orcid.org/0000-0002-0494-7432)
- Yu Gao
- Wenhua Liu
- Xiyuan Lu (ORCID: https://orcid.org/0000-0003-2323-3555)
- Yuyan Lyu
Institutions
- Harbin Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
- Shanghai Cancer Institute (CN)
- Suzhou Municipal Hospital (CN)
- Ministry of Education (TH)
- Heilongjiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1161/circresaha.124.325645
- Citations
- 9
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 8.18