Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2
MMF and MPA exerted broad-spectrum anti-coronavirus effects by inhibiting IMPDH activity. MMF had a synergistic antiviral effect when combined with other drugs, showing its potential clinical antiviral applications.
Authors
- Haiyan Yan (ORCID: https://orcid.org/0009-0000-8780-2601)
- Jian‐Dong Jiang
- Ge Yang (ORCID: https://orcid.org/0000-0002-7023-9143)
- Yuhuan Li (ORCID: https://orcid.org/0000-0003-3725-3258)
- Shuo Wu (ORCID: https://orcid.org/0000-0002-9443-5704)
- Huiqiang Wang (ORCID: https://orcid.org/0000-0002-5956-077X)
- Yongsheng Che (ORCID: https://orcid.org/0000-0003-1126-2754)
- Kun Wang (ORCID: https://orcid.org/0000-0003-2609-6058)
- Mengyuan Wu (ORCID: https://orcid.org/0000-0002-4213-7174)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12985-025-02673-2
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- National Natural Science Foundation of China