Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema
Our findings provide evidence that downregulating uPARAP expression can induce a beneficial remodeling of lymphatic vasculature that attenuates lymphedema through a cell junction-based mechanism, offering a novel therapeutic pathway for lymphedema.
Authors
- Carine Munaut (ORCID: https://orcid.org/0000-0003-4952-9637)
- Sébastien Pirson
- Pascal Brouillard (ORCID: https://orcid.org/0000-0001-9548-8229)
- Louis Baudin
- Kari K. Alitalo (ORCID: https://orcid.org/0000-0002-7331-0902)
- Claire C. Villette (ORCID: https://orcid.org/0000-0002-1638-258X)
- Liesbet Geris (ORCID: https://orcid.org/0000-0002-8180-1445)
- Christophe Nizet (ORCID: https://orcid.org/0000-0001-7814-3691)
- Fabrice Gucciardo (ORCID: https://orcid.org/0000-0001-5462-3471)
- Silvia Blacher
- Marine Gautier‐Isola (ORCID: https://orcid.org/0000-0003-3768-8809)
- Florence Buntinx (ORCID: https://orcid.org/0000-0002-4678-8484)
- Agnès Noël (ORCID: https://orcid.org/0000-0002-7670-6179)
- Florent Morfoisse (ORCID: https://orcid.org/0000-0003-1532-3665)
- Alizée Lebeau (ORCID: https://orcid.org/0000-0002-1144-3232)
- Miikka Vikkula (ORCID: https://orcid.org/0000-0002-6236-338X)
- François Lallemand (ORCID: https://orcid.org/0000-0003-0582-8010)
- Elitsa Ivanova (ORCID: https://orcid.org/0000-0003-1172-500X)
- Jonathan Deroye (ORCID: https://orcid.org/0000-0001-5733-8350)
- Alexandra Pirnay
Institutions
- Inserm (FR)
- University of Liège (BE)
- Wihuri Research Institute (FI)
- de Duve Institute (BE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Circulation
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1161/circulationaha.124.072093
- Citations
- 5
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.23