Allelic frequency of 12-FGF4RG and the association between the genotype with number of calcified intervertebral discs visible on radiographs in Coton de Tuléar and French Bulldog breeds
Our results confirm the significant association between the 12-FGF4RG allele and the number of CDVR and IDC grade in two different chondrodystrophic breeds in age-controlled cohorts of young adult dogs. Our results also suggest that radiographic screening of CDVR and genetic testing of 12-FGF4RG could be used to breed against IVD degeneration predisposing to IVDD.
Authors
- Anu K. Lappalainen (ORCID: https://orcid.org/0000-0002-5675-4771)
- Tarja S. Jokinen (ORCID: https://orcid.org/0000-0001-6389-0109)
- Vilma Reunanen (ORCID: https://orcid.org/0000-0002-6992-2463)
- Marjo K. Hytönen (ORCID: https://orcid.org/0000-0003-1976-5874)
- Liisa Lilja‐Maula (ORCID: https://orcid.org/0000-0001-7198-1529)
Institutions
- University of Helsinki (FI)
- Folkhälsans Forskningscentrum (FI)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12917-025-04573-7
- Citations
- 2
- Primary Topic
- Veterinary Orthopedics and Neurology
- Type
- article
- Field-Weighted Citation Impact
- 4.71
Funders
- Helsingin Yliopisto